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Yet even this high incidence represents only a small fraction of chromosome mutations since the vast majority are lethal and result in prenatal death or stillbirth.
For full explanation of Mendelian and non-Mendelian genetics, genetic mutation and regulation, and other principles underlying genetic disease, Certain human diseases result from mutations in the genetic complement (genome) contained in the deoxyribonucleic acid (DNA) of chromosomes.
Chromosome disorders can be grouped into three principal categories: (1) those that involve numerical abnormalities of the sex chromosomes.
Autosomes are the 22 sets of chromosomes found in all normal human cells.
Meiotic nondisjunction leads to eggs or sperm with additional or missing chromosomes.
Although the biochemical basis of numerical chromosome abnormalities remains unknown, maternal age clearly has an effect, such that older women are at significantly increased risk to conceive and give birth to a chromosomally abnormal child.